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Potential targets for the treatment of MI: GRP75-mediated Ca2+ transfer in MAM

2023-10-22 cardiovascular medicine Title + abstract only
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BackgroundAfter myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function. These alterations are believed to be linked to endoplasmic reticulum (ER) stress, though the specific mechanisms are not fully understood. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. ResultsExcessive oxidative stress was activated in humans post-myo...

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