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Single-nucleus transcriptomics reveals disease- and pathology-specific signatures in α-synucleinopathies

2023-10-10 neurology Title + abstract only
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-synucleinopathies are severe neurodegenerative disorders characterized by intracellular aggregation of -synuclein, yet their molecular pathogenesis remains unknow. Here, we explore cell-specific changes in gene expression across different -synucleinopathies. We perform single-nucleus RNA sequencing (snRNA-seq) on nearly 300,000 nuclei from the prefrontal cortex of individuals with idiopathic Parkinsons disease (iPD), Parkinsons disease caused by LRRK2 mutations (LRRK2-PD), multiple system atrop...

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