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Associations of Combined Phenotypic Aging and Genetic Risk with Incident Cancer: A Prospective Cohort Study

2023-09-27 oncology Title + abstract only
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BackgroundAge is the most important risk factor for cancer, but aging rates are heterogeneous across individuals. We explored a new measure of aging-Phenotypic Age (PhenoAge)-in the risk prediction of site-specific and overall cancer. MethodsUsing Cox regression models, we examined the association of Phenotypic Age Acceleration (PhenoAgeAccel) with cancer incidence by genetic risk group among 374,463 participants from the UK Biobank. We generated PhenoAge using chronological age and 9 biomarker...

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