Prolonged survival of rabid mice after treatment with Poly-ICLC Hiltonol (R)
Brandao, P. E.; Agostinho, W. C.; Caballero, O.; Salazar, A. M.; Gomes, C. O. M. S.
Show abstract
Despite its 100% lethality and approximately 59,000 human deaths a year, rabies is still in want of an effective treatment. A host of trials has been described aiming at impairing the life cycle of Lyssavirus rabies (RABV), the chief worldwide lyssavirus causing rabies, but with limited success. In this study, mice intranasally inoculated with the CVS strain of RABV were serially treated with 50{micro}g/day of the Poly ICLC Hiltonol(R) jn MEM showed significantly higher survival time and disease incubation period as compared to control mice that received MEM only. These very preliminary results indicate that Hiltonol(R) might be an effective drug against rabies that merits wider in vivo investigation.
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- Transmission potential of Culex and Aedes species for Madariaga virus, a member of the eastern equine encephalitis virus complex 94%
- One-year descriptive analysis of patients treated at an anti-rabies clinic - a retrospective study from Kashmir 94%
- Vector competence of Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus mosquitoes for Mayaro virus 94%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Ivermectin reduces coronavirus infection in vivo: a mouse experimental model 95%
- Microbial Metagenomic Approach Uncovers the First Rabbit Haemorrhagic Disease Virus genome in Sub-Saharan Africa 93%
- Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors 93%
Similar papers in this journal
- Utility of recombinant envelope domain III as a diagnostic antigen for the specific detection of Kyasanur Forest Disease 93%
- Genomics of Post-Vaccination SARS-CoV-2 Infections During the Delta Dominated Second Wave of COVID-19 Pandemic, from Mumbai Metropolitan Region (MMR), India 92%
- Upsurge in Hospitalization of Pediatric Patients with Severe Acute Respiratory Infections in Kolkata and Surrounding Districts Caused by Recombinant Human Respiratory Adenovirus Type B 7/3 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.