Sperm Cell Painting: A Mechanism Driven Approach for Drug Discovery in Human Spermatozoa
Barratt, C. L. R.; Johnston, Z. C.; Gruber, F. S.; Swedlow, J. R.; Myles, R.; Kane, S. V.; Richardson, A.; Wilson, C.; Martins da Silva, S.; Gilbert, I. H.; Read, K. D.; Day, D. P.
Show abstract
We have adapted the cell painting assay developed by Carpenter and colleagues on cultured U2OS cells to human spermatozoa. In Sperm Cell Painting (SCP) we assemble an image-based quantitative fingerprint of the functional state of sperm. We use this assay to gain insight into the mechanism of action of compounds that modify sperm function and as a platform for contraceptive discovery.
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