Reduced SV2A and GABAA receptor levels in the brains of type 2 diabetic rats revealed by flumazenil PET
Kong, Y.; Xie, F.; Wang, X.; Zuo, C.; Shi, K.; Rominger, A.; Huang, Q.; Xiao, J.; Jiang, D.; Guan, Y.; Ni, R.
Show abstract
PurposeType 2 diabetes mellitus (T2DM) is associated with a greater risk of Alzheimers disease. Synaptic impairment and protein aggregates have been reported in the brains of T2DM models. Here, we assessed whether neurodegenerative changes in synaptic vesicle 2A (SV2A), {gamma};-aminobutyric acid type A (GABAA) receptor, amyloid-{beta}, tau and receptor for advanced glycosylation end product (RAGE) can be detected in vivo in T2DM rats. MethodsPositron emission tomography (PET) using [18F]SDM-8 (SV2A), [18F]flumazenil (GABAA receptor), [18F]florbetapir (amyloid-{beta}), [18F]PM-PBB3 (tau), and [18F]FPS-ZM1 (RAGE) was carried out in 12-month-old diabetic Zucker diabetic fatty (ZDF) and Sprague{square}Dawley (SD) rats. Proteomic profiling and pathway analysis of the hippocampus of ZDF and SD rats were performed. ResultsReduced cortical [18F]SDM-8 and cortical and hippocampal [18F]flumazenil uptake were observed in 12-month-old ZDF rats compared to SD rats. [18F]florbetapir and [18F]PM-PBB3 uptake were comparable in the brains of 12-month-old ZDF rats and SD rats. ConclusionThe findings provide in vivo evidence for regional reductions in SV2A and GABAA receptor levels in the brains of aged T2DM ZDF rats.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Synthesis and preclinical evaluation of MTP38 as a novel PET ligand for phophodiesterase 7 in the brain 95%
- Preclinical evaluation of the novel CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease 95%
- A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: Synthesis and preclinical characterization of SDM-16 94%
Similar papers in this journal
Similar papers in this journal
- NMR Analysis of the Correlation of Metabolic Changes in Blood and Cerebrospinal Fluid in Alzheimer Model Male and Female Mice 93%
- Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagement in a mouse model of Alzheimer's related amyloid-beta pathology 93%
- Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging 93%
Similar papers in this journal
- A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice 91%
- Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress 91%
- Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration 90%
Similar papers in this journal
- An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with 18 F-PM-PBB3 ( 18 F-APN-1607) 92%
- A High-Resolution In Vivo Atlas of the Human Brain's Benzodiazepine Binding Site of GABAA Receptors 92%
- Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.