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A defined diet for pre-adult Drosophila melanogaster

Martelli, F.; Quig, A.; Mele, S.; Lin, J.; Fulton, T. L.; Wansbrough, M.; Barlow, C. K.; Schittenhelm, R. B.; Johnson, T. K.; Piper, M. D.

2023-08-30 genetics
10.1101/2023.08.28.555220 bioRxiv
Show abstract

Drosophila melanogaster is unique among animal models because it has a fully defined synthetic diet available to study nutrient-gene interactions. However, use of this diet is limited to adult studies due to impaired larval development and survival. Here, we provide an adjusted formula that improves larval growth, development rate, and rescues survival. We demonstrate its use for exploring pre-adult diet compositions of therapeutic potential in a model of an inherited metabolic disorder.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.