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Study of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans suggests a North African origin for Neanderthals

2023-08-22 genetic and genomic medicine Title + abstract only
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BackgroundThe clinical presentation of COVID-19 has shown high variability between individuals, which is partly due to genetic factors. The OAS1/2/3 cluster was found to be strongly associated with COVID-19 severity. We aimed to examine this locus for the occurrence of the critical variant, rs10774671, and its respective haplotype blocks within the Moroccan population. MethodsThe frequency of SNPs at the cluster of OAS immunity genes was assessed from an in-house database in 157 unrelated indiv...

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