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Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease

2023-08-16 neurology Title + abstract only
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Amyloid-{beta} (A{beta}) and tau proteins accumulate within distinct neuronal systems in Alzheimers disease (AD). Although it is not clear why certain brain regions are more vulnerable to A{beta} and tau pathologies than others, gene expression may play a role. We studied the association between brain-wide gene expression profiles and regional vulnerability to A{beta} (gene-to-A{beta} associations) and tau (gene-to-tau associations) pathologies leveraging two large independent cohorts (n = 715) ...

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