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The ABCD-GENE score influences vascular events in users of clopidogrel, aspirin, as well as non-users of either drug

2023-08-09 cardiovascular medicine Title + abstract only
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Background and ObjectivesClopidogrel is an antiplatelet used in both primary and secondary prevention of cardiovascular diseases. It is a prodrug, requiring CYP2C19 for its metabolism to the active metabolite. The ABCD-GENE score, combining clinical attributes (age, body mass index, chronic kidney disease, diabetes mellitus), with genetic information (presence of 1 or 2 loss of function (LOF) alleles in the CYP2C19 gene) has been shown to identify patients with higher risk of recurrent cardiovas...

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