Back

Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Improve Vaccine Immunomodulation

Ou, B. S.; Baillet, J.; Filsinger Interrante, M. V.; Adamska, J. Z.; Zhou, X.; Saouaf, O.; Yan, J.; Klich, J.; Jons, C. K.; Meany, E.; Valdez, A. S.; Carter, L.; Pulendran, B.; King, N. P.; Appel, E.

2023-12-31 bioengineering
10.1101/2023.07.16.549249 bioRxiv
Show abstract

Over the past few decades, the development of potent and safe immune-activating adjuvant technologies has become the heart of intensive research in the constant fight against highly mutative and immune evasive viruses such as influenza, SARS-CoV-2, and HIV. Herein, we developed a highly modular saponin-based nanoparticle platform incorporating toll-like receptor agonists (TLRas) including TLR1/2a, TLR4a, TLR7/8a adjuvants and their mixtures. These various TLRa-SNP adjuvant constructs induce unique acute cytokine and immune-signaling profiles, leading to specific Th-responses that could be of interest depending on the target disease for prevention. In a murine vaccine study, the adjuvants greatly improved the potency, durability, breadth, and neutralization of both COVID-19 and HIV vaccine candidates, suggesting the potential broad application of these adjuvant constructs to a range of different antigens. Overall, this work demonstrates a modular TLRa-SNP adjuvant platform which could improve the design of vaccines for and dramatically impact modern vaccine development. TeaserSaponin-TLRa nanoadjuvants provide distinct immune signatures and drive potent, broad, durable COVID-19 and HIV vaccine responses.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

1
Science Advances
● 1243 papers in training set
Top 0.3%
15.0%
Similar papers in this journal
2
ACS Nano
● 113 papers in training set
Top 0.1%
10.5%
Similar papers in this journal
3
Nature Communications
○ 5641 papers in training set
Top 21%
7.8%
Similar papers in this journal
4
Science Translational Medicine
● 127 papers in training set
Top 0.2%
6.2%
Similar papers in this journal
5
Advanced Science
○ 286 papers in training set
Top 0.9%
6.2%
Similar papers in this journal
6
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 10%
4.8%
50% of probability mass above
7
Journal of Controlled Release
○ 44 papers in training set
Top 0.2%
4.8%
8
Biomaterials
○ 84 papers in training set
Top 0.5%
4.0%
9
Molecular Therapy
○ 81 papers in training set
Top 0.4%
3.5%
10
eLife
● 5828 papers in training set
Top 39%
2.7%
11
Nature Biomedical Engineering
○ 47 papers in training set
Top 0.5%
2.4%
12
Advanced Materials
○ 56 papers in training set
Top 0.6%
1.7%
13
npj Vaccines
○ 67 papers in training set
Top 0.5%
1.7%
14
Nature Nanotechnology
○ 32 papers in training set
Top 0.4%
1.5%
15
Molecular Therapy - Methods & Clinical Development
○ 38 papers in training set
Top 0.4%
1.3%
16
Small
○ 78 papers in training set
Top 1%
1.3%
17
ACS Central Science
● 71 papers in training set
Top 0.9%
1.3%
18
mBio
● 833 papers in training set
Top 9%
1.1%
19
Bioengineering & Translational Medicine
○ 21 papers in training set
Top 0.4%
1.1%
20
iScience
○ 1154 papers in training set
Top 27%
1.1%
21
Cell Reports
○ 1498 papers in training set
Top 23%
1.1%
22
Advanced Therapeutics
○ 17 papers in training set
Top 0.2%
1.0%
23
Advanced Healthcare Materials
○ 85 papers in training set
Top 1%
1.0%
24
Vaccines
○ 198 papers in training set
Top 3%
1.0%
25
Cell
○ 431 papers in training set
Top 10%
0.8%
26
Frontiers in Immunology
○ 638 papers in training set
Top 10%
0.8%
27
JCI Insight
● 277 papers in training set
Top 9%
0.6%
28
Vaccine
○ 203 papers in training set
Top 2%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.