Acute targeted induction of gut-microbial metabolism disrupts host circadian rhythm
Greter, G.; Oswald, S.; Kuenzli, D.; Lan, J.; Slack, E.; Arnoldini, M.
Show abstract
The gut microbiota and host circadian clock mutually influence each other, and microbiota metabolism has been shown to play a role in regulating host circadian function via secretion of fermentation products. Microbial metabolism is dependent on the availability of nutrients for the microbiota, typically through the hosts food intake, making it challenging to disentangle the effect of host and microbiota metabolism. In this study, we acutely induced gut microbial metabolic activity without inducing host metabolism in mice. We found that increasing microbial metabolism in the gut altered circadian clock gene expression locally. Actuating microbiota metabolism also reduced host food intake beyond the calories provided by the microbiota, suggesting a systemic signaling effect of microbial metabolism on the host.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The host genotype actively shapes its microbiome across generations 95%
- A mouse model of occult intestinal colonization demonstrating antibiotic-induced outgrowth of carbapenem-resistant Enterobacteriaceae 94%
- Microbiota responses to different prebiotics are conserved within individuals and associated with habitual fiber intake 94%
Similar papers in this journal
- Prebiotics and community composition influence gas production of the human gut microbiota 94%
- Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis 93%
- Short-chain fatty acid production by gut microbiota from children with obesity is linked to bacterial community composition and prebiotic choice 93%
Similar papers in this journal
- Enhancing Recovery from Gut Microbiome Dysbiosis and Alleviating DSS-Induced Colitis in Mice with a Consortium of Rare Short-Chain Fatty Acid-Producing Bacteria 95%
- Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processes 94%
- A history of repeated antibiotic usage leads to microbiota-dependent mucus defects 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.