Non-Invasive Imaging Modalities in Coronary Artery Disease: A meta analysis comparing CCTA and Standard of Care (SOC)

IntroductionCoronary Artery Disease has become a global pandemic and a major cause of death especially among Older population. The risk factor calculation or the degree of Coronary artery damage is usually an invasive procedure. A paradigm change has occurred in the last ten years regarding the assessment of coronary artery disease (CAD) utilising coronary computed tomography angiography (CCTA). Aims and ObjectivesTo Comapre CCTA with Standard Care to calculate the need of revascularization, invasive coronary angiography as well as to compare both for MI and All cause mortality ResultsCCTA was found to be associated with a significant increase in revascularizations (RR =1.401, 95% CI =1.315-1.492, p<0.001) as well as invasive coronary angiography procedures (RR =1.304, 95% CI =1.208-1.409, p<0.001). However, it was associated with decreased incidences of MI (RR =0.752, 95% CI =0.578-1.409, p<0.033). There was no significant association with all-cause mortality. ConclusionCCTA is significantly correlated with a reduction in MI episodes and an increase in revascularizations and ICA procedures. However, it was found that it had no effect on all-cause mortality. On the contrary, standard care approaches were associated with greater rates of MI but lesser referrals for invasive coronary angiography and revascularization.