African Swine Fever Virus major capsid p72 Trimers function as a pH sensor during uncoating process of virus endocytosis
Meng, K.; Huyan, Y.; Liu, Q.; Li, J.; Xiang, Y.; Meng, G.
Show abstract
African swine fever virus (ASFV) belongs to nucleocytoplasmic large DNA viruses (NCLDVs), the only member of Asfarviridae. So far, it is revealed that the ASFV uncoating is a pH-dependent process undergone in late endosomes. But, the research on how pH affects capsid stability is limited, and which protein plays an essential role in pH sensing remains unknown. In this study, we identified the main component of the ASFV capsid -- major capsid protein p72, as a pH sensitive residue abundance protein, and it is speculated that the conformational change of the p72 trimer is possibly responsible for the ASFV uncoating process. To test this speculation, we obtained recombinant p72 trimers, treated with the acidic environment that simulated endosomes and displayed structural analysis. The results showed that the p72 trimer depolymerized at low pH. The depolymerization of trimers rationally explains the disassembly mechanism of the ASFV icosahedral capsid in endosomes.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- AGPAT1 is a novel Chikungunya virus receptor on human cells 94%
- Mosquito defensins enhance Japanese encephalitis virus infection by facilitating virus adsorption and entry within mosquito 94%
- Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation 94%
Similar papers in this journal
- Inhibition of BET family proteins suppresses African swine fever virus infection 94%
- Genetic diversity and characterization of circular replication(Rep)-encoding single-stranded (CRESS) DNA viruses 94%
- RG203KR mutations in SARS-CoV-2 Nucleocapsid: Assessing the impact using Virus-like particle model system 93%
Similar papers in this journal
- Antigenic evolution on global scale reveals potential natural selection of SARS-CoV-2 by pre-existing cross-reactive T cell immunity 94%
- Modulation of viral replication, autophagy and apoptosis by induction and mutual regulation of transcription factors EB and E3 during coronavirus infection 93%
- The discovery of a recombinant SARS2-like CoV strain provides insights into SARS and COVID-2019 pandemics 93%
Similar papers in this journal
- CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreatitis 93%
- An Arginine-Rich Motif in the ORF2 Capsid Protein Regulates the Hepatitis E Virus Lifecycle and Interactions with the Host Cell 93%
- piR-bmo-796514 Facilitates the Proliferation of Exogenous DNA Virus (Baculovirus) by Targeting the Host E3 Ubiquitin Ligase RNF181 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.