Ferroptosis induced by phenolic compound-iron complex
Sui, X.; Wang, J.; Zhao, Z.; Liu, B.; Liu, M.; Liu, M.; Shi, C.; Feng, X.; Fu, Y.; Shi, D.; Li, S.; Qi, Q.; Xian, M.; Zhao, G.
Show abstract
Phenolic compounds are the most ubiquitously distributed pollutants, and are highly toxic to living organisms, however the detailed mechanism how phenols exert toxic effects remains elusive. Here,Escherichia coli and phloroglucinol are adapted as proxy to elucidate the molecular mechanism of phenols toxicity. We demonstrated that phloroglucinol complexed with iron and promoted the generation of hydroxyl radicals in Fenton reaction, leading to reducing power depletion and lipid peroxidation, and further leading to ferroptosis-like cell death ofE. coli. This ferroptotic death can be triggered by various phenols in diverse organisms, from bacteria to mammalian cells. Furthermore, we demonstrated that phloroglucinol-induced ferroptosis suppressed tumor growth in mice effectively, indicating phloroglucinol as promising drug for therapy-resistant cancers. Its also discovered that repression of this ferroptosis-like cell death benefited microbial degradation or production of desired phenolic compounds, showing great application potential in biotechnology field.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A marine bacterial community that degrades poly(ethylene terephthalate) and polyethylene 93%
- Classification of the glyphosate target enzyme (5-enolpyruvylshikimate-3-phosphate synthase) 93%
- Machine Learning-based Biomarkers Identification and Validation from Toxicogenomics - Bridging to Regulatory Relevant Phenotypic Endpoints 90%
Similar papers in this journal
- Streptomyces alleviate abiotic stress in plant by producing pteridic acids 95%
- Genome-wide targets identification by CRISPRi-Omics for high-titer production of free fatty acids in Escherichia coli 95%
- Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus 94%
Similar papers in this journal
- Subcellular Redox Responses Reveal Different Cu-dependent Antioxidant Defenses between Mitochondria and Cytosol 93%
- WITHDRAWN: Nitrogen sources enhance siderophore-mediated competition for iron between potato common scab and late blight causative agents 92%
- Development of affinity beads-based in vitro metal-ligand binding assay reveals dominant cadmium affinity of thiol-rich small peptides phytochelatins beyond glutathione 92%
Similar papers in this journal
- Functional roles of multiple Ton complex genes in a Sphingobium degrader of lignin-derived aromatic compounds 94%
- A Penicillium rubens platform strain for secondary metabolite production 93%
- Radical Cation Scavenging Activity Of Berberine Bridge Enzyme-Like Oligosaccharide Oxidases Acting On Short Cell Wall Fragments. 93%
Similar papers in this journal
- Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity 94%
- Merging Multi-OMICs with Proteome Integral Solubility Alteration Unveils Antibiotic Mode of Action 94%
- A toxin-mediated policing system in Bacillus improves population fitness via penalizing non-cooperating phenotypic cheaters 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.