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Single-cycle SARS-CoV-2 vaccine elicits high protection and sterilizing immunity in hamsters

Lett, M. J.; Otte, F.; Hauser, D.; Schoen, J.; Kipfer, E. T.; Hoffmann, D.; Halwe, N. J.; Ulrich, L.; Zhang, Y.; Cmiljanovic, V.; Wylezich, C.; Urda, L.; Lang, C.; Beer, M.; Mittelholzer, C.; Klimkait, T.

2023-05-17 molecular biology
10.1101/2023.05.17.541127 bioRxiv
Show abstract

Vaccines have been central in ending the COVID-19 pandemic, but newly emerging SARS-CoV-2 variants increasingly escape first-generation vaccine protection. To fill this gap, live particle-based vaccines mimicking natural infection aim at protecting against a broader spectrum of virus variants. We designed "single-cycle SARS-CoV-2 viruses" (SCVs) that lack essential viral genes, possess superior immune-modulatory features and provide an excellent safety profile in the Syrian hamster model. Full protection of all intranasally vaccinated animals was achieved against an autologous challenge with SARS-CoV-2 virus using an Envelope-gene-deleted vaccine candidate. By deleting key immune-downregulating genes, sterilizing immunity was achieved with an advanced candidate without virus spread to contact animals. Hence, SCVs have the potential to induce a broad and durable protection against COVID-19 superior to a natural infection.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.