Patterns of early neocortical amyloid beta accumulation: a positron emission tomography population-based study
Lecy, E. E.; Min, H.-K.; Apgar, C. J.; Maltais, D. D.; Lundt, E. S.; Albertson, S. M.; Senjem, M. L.; Schwarz, C. G.; Botha, H.; Graff-Radford, J.; Jones, D. T.; Vemuri, P.; Kantarci, K.; Knopman, D. S.; Petersen, R. C.; Jack, C. R.; Lee, J.; Lowe, V. J.
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IntroductionThe widespread deposition of amyloid beta (A{beta}) plaques in late-stage Alzheimers disease (AD) is well defined and confirmed by in vivo positron emission tomography (PET). However, there are discrepancies between which regions contribute to the earliest topographical A{beta} deposition within the neocortex. MethodsThis study investigated A{beta} signals in the peri-threshold SUVr range using Pittsburgh compound B (PiB) PET in a population-based study cross-sectionally and longitudinally. PiB-PET scans from 1,088 participants were assessed to determine the early patterns of PiB loading in the neocortex. ResultsEarly-stage A{beta} loading is seen first in the temporal, cingulate, and occipital regions. Regional early deposition patterns are similar in both Apolipoprotein {varepsilon}4 (APOE) carriers and non-carriers. Hierarchical clustering analysis shows groups with different patterns of early amyloid deposition. DiscussionThese finding of initial A{beta} deposition patterns may be of significance for diagnostics and understanding the development of different AD phenotypes.
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