A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila
Pandey, P.; Wall, P. K.; Lopez, S. R.; Dubuisson, O. S.; Zunica, E. R. M.; Dantas, W. S.; Kirwan, J. P.; Axelrod, C. L.; Johnson, A. E.
Show abstract
Sleep loss typically imposes negative effects on animal health. However, humans with a rare genetic mutation in the dec2 gene (dec2P384R) present an exception; these individuals sleep less without the usual effects associated with sleep deprivation. Thus, it has been suggested that the dec2P384R mutation activates compensatory mechanisms that allows these individuals to thrive with less sleep. To test this directly, we used a Drosophila model to study the effects of the dec2P384Rmutation on animal health. Expression of human dec2P384R in fly sleep neurons was sufficient to mimic the short sleep phenotype and, remarkably, dec2P384R mutants lived significantly longer with improved health despite sleeping less. The improved physiological effects were enabled, in part, by enhanced mitochondrial fitness and upregulation of multiple stress response pathways. Moreover, we provide evidence that upregulation of pro-health pathways also contributes to the short sleep phenotype, and this phenomenon may extend to other pro-longevity models.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators 95%
- Replication competition drives the selective mtDNA inheritance in Drosophila ovary 94%
- Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.