Serum from pregnant donors induces human beta cell proliferation and insulin secretion
Sylvester-Armstrong, K. R.; Reeder, C. F.; Powell, A.; Becker, M. W.; Hagan, D. W.; Chen, J.; Mathews, C. E.; Wasserfall, C. H.; Atkinson, M. A.; Egerman, R.; Phelps, E. A.
Show abstract
Pancreatic beta cells are among the slowest replicating cells in the human body. Human beta cells usually do not increase in number with exceptions being during the neonatal period, in cases of obesity, and during pregnancy. This project explored maternal serum for stimulatory potential on human beta cell proliferation and insulin output. Gravid, full-term women who were scheduled to undergo cesarean delivery were recruited for this study. A human beta cell line was cultured in media supplemented with serum from pregnant and non-pregnant donors and assessed for differences in proliferation and insulin secretion. A subset of pregnant donor sera induced significant increases in beta cell proliferation and insulin secretion. Pooled serum from pregnant donors also increased proliferation in primary human beta cells but not primary human hepatocytes indicating a cell-type specific effect. This study suggests stimulatory factors in human serum during pregnancy could provide a novel approach for human beta cell expansion.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Differential effects of voclosporin and tacrolimus on insulin secretion from human islets 94%
- Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion from Human Islets 93%
- β-Hydroxybutyrate promotes basal insulin secretion while decreasing glucagon secretion in mouse and human islets. 93%
Similar papers in this journal
- Replacing murine insulin 1 with human insulin protects NOD mice from diabetes 94%
- Identification of a small molecule that stimulates human beta-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells 94%
- Hypusinated eIF5A is expressed in pancreas and spleen of individuals with type 1 and type 2 diabetes 93%
Similar papers in this journal
- High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester 91%
- Establishment and Characterization of a New Immortalized Human Adenomyosis Epithelial-Like Cell Line, tAEC21 91%
- A mouse model of maternal obesity leads to uterine natural killer (uNK) cell activation and uterine artery remodeling defects 91%
Similar papers in this journal
- Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans 93%
- Divergent Cell-Type Specific Hypoxia Responses in Human Stem Cell-Derived and Primary Islets 91%
- Maternal and cord-blood inflammatory markers and BDNF in diabetic vs non-diabetic pregnancies 91%
Similar papers in this journal
- Proinflammatory cytokine-induced alpha-cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism 94%
- Pancreatic Beta Cell Autophagy is Impaired in Type 1 Diabetes 92%
- Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.