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Transcriptomic analyses reveal regional signatures in lung allograft recipients
2023-04-03
transplantation
Title + abstract only
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BackgroundLong term outcomes of allograft recipients are compromised by the development of chronic lung allograft dysfunction (CLAD) promoting bronchiolitis obliterans syndrome (BOS). We established baseline transcriptomic profiles of both the large and small airway epithelial cells (referred as LAEC and SAEC, respectively) to identify regional differences irrespective of initiating disease. MethodsWe obtained matched primary LAEC and SAEC from lung allograft recipients (n=4, 42.5 {+/-} 4.2 yea...
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