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Re-evaluating the nuclear staining on pathological sections in Alzheimer's disease

Fu, H.; Li, J.; Zhang, C.; Du, P.; Gao, G.; Ge, Q.; Guan, X.; Cui, D.

2023-03-24 neuroscience
10.1101/2023.03.22.533761 bioRxiv
Show abstract

A paper recently published on Nature Neuroscience, asserting that lysosome leakage induces neuronal cell death and the formation of senile plaques in Alzheimers disease. The study believed that flower-like perikaryal rosettes formed by packed autophagic vacuoles around central nuclei, termed "PANTHOS" neurons, are responsible for the senile plaque formation. However, all of the nuclei staining in this paper based on images in the blue fluorescence channel. We did detailed studies on the senile plaque blue autofluorescence and found that senile plaque blue autofluorescence could be easily mistaken as nuclear staining. The blue "nuclear" staining in this paper is probably inaccurate since it was not verified in red or green fluorescence channels and their "nuclei"-related data might be mis-interpreted.

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