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Ultra fast oscillations in the human brain and their functional significance

Brazdil, M.; Worrell, G. A.; Travnicek, V.; Pail, M.; Roman, R.; Plesinger, F.; Klimes, P.; Cimbalnik, J.; Stacey, W.; Jurak, P.

2023-02-26 neurology
10.1101/2023.02.23.23285962 medRxiv
Show abstract

Human brain cell assemblies fire electrical impulses up to very high frequencies, which limit is not yet known. Using advanced intracranial microEEG recordings in a cohort of epileptic patients, we newly identified short-lasting oscillations in frequencies between 2 and 8 kHz. These ultra fast oscillations were consistently and locally detected in epileptic hippocampi but were extremely rare in non-epileptic brain tissue. The discovered electrophysiological phenomena thus may reflect neuronal hyperexcitability.

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