Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation
Yang, A.; Zeng, W.; Hao, Y.; Zhang, H.; Wang, Q.; Sun, Y.; Quan, S.; Ding, N.; Yang, X.; Sun, J.; Zhang, H.; Liu, B.; Jiao, Y.; Wu, K.; Jiang, Y.
Show abstract
Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. High levels of homocysteine (Hcy) promote autophagy in hepatocytes, but the underlying mechanism is still unknown. Here, we investigated the relation between Hcy increased autophagy levels and the expression of nuclear transcription factor EB (TFEB). We demonstrate that Hcy increased autophagy levels is mediated by upregulation of TFEB. Silencing TFEB decreases the autophagy-related protein LC3BII/I and increases p62 expression levels in hepatocytes after exposure to Hcy. Moreover, the effect of Hcy on the expression of TFEB is regulated by hypomethylation of TFEB promoter catalyzed by DNA methyltransferase 3b (DNMT3b). In summary, this study shows that Hcy can activate autophagy by inhibiting DNMT3b-mediated DNA methylation and upregulating TFEB expression. These findings provide another new mechanism for Hcy-induced autophagy in hepatocytes.
Matching journals
The top 15 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges 95%
- The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway 94%
- Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in chronic liver disease rats and humans 93%
Similar papers in this journal
- Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells 92%
- Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus Susceptibility 92%
- Vagus nerve mediated liver-brain axis is a major regulator of the metabolic landscape in the liver 92%
Similar papers in this journal
- Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease 93%
- Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoid in lipopolysaccharide-treated HEI-OC1 cells through modulation of Foxp3/Nrf2 signaling pathway 93%
- Scutellarin inhibits ferroptosis by promoting cellular antioxidant capacity through regulating the Nrf2 signaling 92%
Similar papers in this journal
- PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response 94%
- The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages 93%
- P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.