MNRR1 activation by nitazoxanide abrogates lipopolysaccharide- induced preterm birth in mice
Purandare, N.; Gomez-Lopez, N.; Arenas-Hernandez, M.; Galaz, J.; Romero, R.; Xi, Y.; Fribley, A.; Grossman, L. I.; Aras, S.
Show abstract
Intra-amniotic inflammation leading to preterm birth is one of the leading causes of neonatal morbidity and mortality. We recently found that the mitochondrial levels of MNRR1 (Mitochondrial Nuclear Retrograde, Regulator 1; also called CHCHD2, AAG10, or PARK22), an important bi-organellar regulator of cellular function, are reduced in the context of inflammation and that both genetic and pharmacological increase in MNRR1 levels can counter the inflammatory profile. We show here that nitazoxanide, a clinically-approved drug, is an activator of MNRR1 and prevents preterm birth in a well-characterized murine model caused by intra-amniotic lipopolysaccharide (LPS) injection. HighlightsO_LINitazoxanide exerts anti-inflammatory functions via activation of MNRR1. C_LIO_LIOral administration of nitazoxanide prevents preterm birth in mouse model of intra-intraamniotic LPS-induced inflammation. C_LI
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- MYB and ELF3 differentially modulate labor-inducing gene expression in myometrial cells 95%
- Urinary prostaglandin metabolites as biomarkers for human labour: Insights into future predictors 94%
- Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births 94%
Similar papers in this journal
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis 92%
- Immune and pathophysiologic profiling of antenatal COVID-19 in the GIFT cohort: A Singaporean case-control study 92%
- Alterations in excitatory and inhibitory synaptic development within the mesolimbic dopamine pathway in a mouse model of prenatal drug exposure 92%
Similar papers in this journal
- Placenta hIGF1 nanoparticle treatment in guinea pigs mitigates fetal sex dependent FGR-associated effects on kidney structure and blood pressure-related signaling pathways 93%
- Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation 92%
- A direct estrogenic involvement in the expression of human hypocretin 91%
Similar papers in this journal
- Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in myoblasts by modulating the β-catenin/NF-κB signaling pathway 91%
- Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19 91%
- Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects in microglia 90%
Similar papers in this journal
- Fibroblast activation during decidualization: Embryo-derived TNFα induction of PGI2-PPARδ-ACTIVIN A pathway through luminal epithelium 94%
- Interleukin-33 stimulates stress in the endoplasmic reticulum of the human myometrium via an influx of calcium during initiation of labor 94%
- ACVR2A Facilitates Trophoblast Cell Invasion through TCF7/c-JUN Pathway in Pre-eclampsia Progression 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.