Genomic and Proteomic Analysis of Patients with Reoccurring Discrete Subaortic Stenosis
Birla, R.; Singampalli, K. L.; Nieuwsma, A.; Brimmer, S. A.; Kaul, A.; Wadhwa, L.; Jung, S. Y.; Mezquita, D.; Grimm, S. L.; Balaji, S.; Coarfa, C.; Caldarone, C. A.; Grande-Allen, K. J.; Keswani, S. G.
Show abstract
Discrete subaortic stenosis (DSS) is a pediatric condition in which a fibrotic membrane forms within the left ventricular outflow track. The fibrotic membrane is removed surgically; however, there is a high rate of reoccurrence which requires a second surgery. There are currently no tools available to predict the risk of reoccurrence in DSS patients, a limitation addressed by this study. In this study, we analyzed resected fibrotic membranes for DSS patients at the time of first surgery for non-recurrent and recurrent patients, and at the time of second surgery for recurrent patients. RNA-sequencing was conducted to obtain a global screen of changes in RNA expression while mass spectrometry was used to obtain a global screen of changes in protein expression. The results from the RNA-sequencing and mass spectrometry provide valuable insight into genes and the proteins that are differentially regulated in recurrent vs non-recurrent DSS patients.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Altered kinetics of circulating progenitor cells in cardiopulmonary bypass (CPB) associated vasoplegic patients: A pilot study 94%
- Transection injury differentially alters the proteome of the human sural nerve 94%
- Generation and characterization of two immortalized dermal fibroblast cell lines from the spiny mouse (Acomys) 94%
Similar papers in this journal
- Transciptomic Analysis of the Effect of Remote Ischaemic Conditioning in an Animal Model of Necrotising Enterocolitis 94%
- Roles of sarcoplasmic reticulum Ca2+ ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model 93%
- Exploration of phosphoproteomic association during epimorphic regeneration 93%
Similar papers in this journal
- Data independent acquisition mass spectrometry (DIA-MS) analysis of FFPE rectal cancer samples offers in depth proteomics characterization of response to neoadjuvant chemoradiotherapy 94%
- Mast cells differentiated in synovial fluid and resident in osteophytes exalt the inflammatory pathology of osteoarthritis 93%
- Protein profiling of WERI RB1 and etoposide resistant WERI ETOR reveals new insights into topoisomerase inhibitor resistance in retinoblastoma 93%
Similar papers in this journal
- Global profiling of the proteome and acetylome in mice with abdominal aortic aneurysms 93%
- COVID-19 ORF3a Viroporin Influenced Common and Unique Cellular Signalling Cascades in Lung, Heart and Brain Choroid Plexus Organoids with Additional Enriched MicroRNA Network Analyses for Lung and Brain Tissues 92%
- Baicalein ameliorates experimental ulcerative colitis recurrency by downregulating neonatal Fc receptor via the NF-κB signaling pathway 91%
Similar papers in this journal
- Panomics reveals patient-individuality as the major driver for colorectal cancer progression 93%
- Vibrational Spectroscopy Identifies Myocardial Chemical Modifications in Heart Failure with Preserved Ejection Fraction 92%
- Integration of Machine Learning to Identify Diagnostic Genes in Leukocytes for Acute Myocardial Infarction Patients 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.