Unique amino acid substitution in RBD region of SARS-CoV-2 Omicron XAY.2
Salsekar, L.; Rahangdale, S.; Tamboli, E.; Khairnar, K.
Show abstract
We attempted to explain the rare mutation at the receptor binding domain of the spike protein in the XAY.2 variant of SARS-CoV-2 from the perspective of hydrophobic interactions. We propose that decreasing hydrophobicity at position 446 and 486 of the RBD region of the spike protein might affect the infectivity of SARS-CoV-2. We also estimated the probable mutations at the 446 and 486 position the virus may acquire, leading to a decreased hydrophobicity.
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