Dynamics of lipidome in a colon simulator
Krakstrom, M.; Alves, M. A.; Dickens, A. M.; Forssten, S. D.; Ouwehand, A. C.; Hyotylainen, T.; Oresic, M.; Lamichhane, S.
Show abstract
Current evidence suggests that gut microbiome derived lipids play crucial role in the regulation of host lipid metabolism. However, not much is known about the dynamics of gut microbial lipids within the distinct gut biogeographic. Here we employed targeted and untargeted lipidomics in the in vitro derived feces. Simulated intestinal chyme was collected from in vitro gut vessels (V1-V4), representing proximal to distal parts of the colon after 24 and 48 h with/without PDX treatment. In total 44 simulated chyme samples were collected from the in vitro colon simulator. Factor analysis showed that vessel and time had the strongest impact on the simulated intestinal chyme lipid profiles. We found that levels of phosphatidylcholines, sphingomyelins, triacylglycerols and endocannabinoids were altered in at least one vessel (V1-V4) during simulation. We also found that concentrations of triacylglycerols, diacylglycerols and endocannabinoids changed with time (24 vs. 48 h simulation). Together, we found that the simulated intestinal chyme revealed a wide range of lipids that remained altered in different compartments of the human colon model over time.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Analysis of human colostrum reveals differential co-occurrence networks of metabolites, microbiota, and cytokines in maternal obesity 95%
- Digestion, fermentation, and pathogen anti-adhesive properties of the hMO-mimic di-fucosyl-β-cyclodextrin 94%
- Probiotic strains improve high-fat diet-induced hypercholesterolemia through modulating gut microbiota in ways different from atorvastatin 94%
Similar papers in this journal
- The Biochemical Effects of Carotenoids in Orange Carrots on the Colonic Proteome in a Mouse Model of Diet-induced Obesity 96%
- Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program 93%
- Liver Protein Expression in NASH Mice on a High-Fat Diet 93%
Similar papers in this journal
- Dietary cystine restriction increases the proliferative capacity of the small intestine of mice 95%
- Secondary bile acid ursodeoxycholic acid (UDCA) alters weight, the gut microbiota, and the bile acid pool in conventional mice 95%
- Impact of time and temperature on gut microbiota and SCFA composition in stool samples 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.