A Binary RNA and DNA Self-Amplifying Platform for Next Generation Vaccines and Therapeutics
Jefferies, W.; Choi, K. B.; Ribeca, P.; Kari, S.; Young, J.; Hui, E.; Qi, S. Y.; Garrosvillas, E.; Lincez, P.; Welch, T.; Saranchova, I.; Pfeifer, C. G.
Show abstract
Conventional mRNA-based vaccines were instrumental in lowering the burden of the pandemic on healthcare systems and in reducing mortality. However, such first-generation vaccines have significant weaknesses. Here, we describe a high-performance binary recombinant vectoral platform offering the flexibility to be used as a self-amplifying mRNA or a self-amplifying DNA. Both formats drive long-lasting expression and actuate robust antibody responses against SAR-CoV-2 spike, and neither format require encapsulation with lipid nanoparticles (LNP) in the generation immune responses. The platform combines the power of conventional mRNA with the low-dosage of self-amplifying vectors together with the simplicity, rapid creation, ease of storage, and convenience of distribution of plasmid DNA vectors. This platform promises to pave the way for more effective, less expensive, and truly democratized vaccines and therapeutics. One-Sentence SummaryGemini: a versatile platform that improves on existing vaccine formats in terms of effectiveness, manufacturing, distribution, and cost.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19 96%
- A Single Dose of Self-Transcribing and Replicating RNA Based SARS-CoV-2 Vaccine Produces Protective Adaptive Immunity In Mice 96%
- Corticosteroids and cellulose purification improve respectively the in vivo translation and vaccination efficacy of self-amplifying mRNAs 95%
Similar papers in this journal
- mRNA vaccines encoding membrane-anchored receptor-binding domains of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting 95%
- Correlating physicochemical and biological properties to define critical quality attributes of a recombinant AAV vaccine candidate 95%
- Hypoxia-directed tumor targeting of CRISPR/Cas9 and HSV-TK suicide gene therapy using lipid nanoparticles 94%
Similar papers in this journal
- Self-multimerization of mRNA LNP-derived antigen improves antibody responses 96%
- Multivalent Exosome based protein vaccine: a "mix and match" approach to epidemic viruses' challenges. 96%
- Long-term Immunity of a Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Irradiated by Gamma Rays in Mice 96%
Similar papers in this journal
- AAVone: A Cost-Effective, Single-Plasmid Solution for Efficient AAV Production with Reduced DNA Impurities 94%
- Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cells 93%
- A novel miniaturized filamentous phagemid as a gene delivery vehicle to target mammalian cells 93%
Similar papers in this journal
- A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability 96%
- mRNA-based vaccine candidate COReNAPCIN(R) induces robust humoral and cellular immunity in mice and non-human primates 96%
- PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.