Suppression of classical renin-angiotensin system and increase of soluble ACE2 in pregnancies with adverse outcomes

2022-11-29 obstetrics and gynecology Title + abstract only

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Hypertension during pregnancy increases the risk for adverse maternal and fetal outcomes, but mechanisms of pregnancy hypertension are not precisely understood. Elevated plasma renin activity and aldosterone concentrations play an important role in the normal physiologic adaptation to pregnancy. These effectors are reduced in patients with pregnancy hypertension, creating an opportunity to define features of the renin-angiotensin-aldosterone system (RAAS) that are characteristic of this disorder...

Suppression of classical renin-angiotensin system and increase of soluble ACE2 in pregnancies with adverse outcomes

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