Impaired HIV-specific T-cell responses in HIV and S. mansoni coinfected Ugandans.
Obuku, A. E.; Sharma, A. A.; Rukundo, A.; Odong, M.; Auma, B.; Serwanga, J. S.; Nkangi, R.; Nakitto, Z.; Joloba, M.; Pantaleo, G.; Kaleebu, P.; Sekaly, R. P.
Show abstract
Fishing communities surrounding Lake Victoria in Uganda show an HIV-1 prevalence of 28% and incidence rates of 5%. More than 50% of the fishermen on the shores of Lake Victoria are infected with S. mansoni. Fishermen are more likely to die of AIDS related illness than farmers in the Lake Victoria region. Using polychromatic flow cytometry and mesoscale discovery platform, HIV specific and non-specific responses were measured and compared within individuals when HIV and S. mansoni coinfected and after the S. mansoni was cleared. Sixty-two unique clusters of cells in the UMAP space were identified after stimulations with GAG PTE POOL-1 and GAG PTE POOL-2 independently. However, the frequency of only three clusters is significantly higher after S. mansoni clearance. In addition, S. mansoni infection is associated with higher IL-9 and IL-10 and lower IL-15 in HIV and S. mansoni coinfected individuals. IL-9 concentration at enrolment visit predicts CD4 decline. S. mansoni infection negatively affects HIV specific and non-specific immune responses in HIV and S. mansoni coinfected individuals.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Th22 cells are a major contributor to the mycobacterial CD4+ T cell response and are depleted during HIV infection 93%
- CD4+ Mucosal-associated Invariant T (MAIT) cells express highly diverse T cell receptors 93%
- Characterization of Mycobacterium tuberculosis -specific Th22 cells and the effect of tuberculosis disease and HIV co-infection 93%
Similar papers in this journal
- A whole blood intracellular cytokine assay optimised for field site studies demonstrates polyfunctionality of CD4+ T cells in acute scrub typhus 95%
- Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature 94%
- Altered co-stimulatory and inhibitory receptors on monocyte subsets in patients with visceral leishmaniasis 93%
Similar papers in this journal
- Single-Cell Transcriptomics Unveils Skin Cell Specific Antifungal Immune Responses and IL-1Ra- IL-1R Immune Evasion Strategies of Emerging Fungal Pathogen Candida auris 94%
- Pre-vaccination Frequency of Circulatory Tfh is associated with Robust Immune Response to TV003 Dengue Vaccine 94%
- The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming 94%
Similar papers in this journal
- Induction of an early IFN-γ cellular response and high plasma levels of SDF-1α are inversely associated with COVID-19 severity and residence in rural areas in Kenyan patients 95%
- BCG activation of trained immunity is associated with induction of cross reactive COVID-19 antibodies in a BCG vaccinated population. 94%
- CHARM: COVID-19 Health Action Response for Marines - association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 test 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.