The Lactate Gradient, an unrecognized biomarker of potential significance
Fabricius, T.
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BackgroundHuman lactate formation is typically attributed to hypoxia, but it may actually be due to the influence of norepinephrine. MethodsA lactate gradient was measured from the first few drops of blood obtained after application of a lancet to a finger pad. However, the blood needed to be carefully obtained according to this protocol. ResultsThe measured lactate gradient was surprisingly large in some circumstances, and was not correlated with any of the other measured parameters such as oxygen or carbon dioxide blood levels. There were hints in the data that the lactate gradient seemed to be influenced by sympathetic noradrenergic nervous system activity. ConclusionsThe lactate gradient is relatively easily obtainable, and may reflect conditions causing enhanced sympathetic activity.
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