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Formation of pericentromeric heterochromatin via ZNF518 that links satellite DNA to heterochromatin

Ohta, S.; Ohzeki, J.-I.; Sato, N.; Noma, K.-I.; Masumoto, H.

2022-09-16 cell biology
10.1101/2022.09.15.508097 bioRxiv
Show abstract

Aneuploidy is caused by chromosomal missegregation and is frequently observed in cancers and hematological diseases. Pericentromeric heterochromatin formation is essential for proper chromosome segregation; however, it is unclear how heterochromatin is targeted to pericentromeres. In this study, we investigated the involvement of two homologous zinc-finger proteins (ZNF518A and ZNF518B) in heterochromatin formation at pericentromeres by determining the cellular localization of ZNF518, centromeric proteins such as CENP-A and CENP-B, and heterochromatin factors, including HP1 and histone H3K9 trimethylation. The results showed that various segments in ZNF518 interact with CENP-B, HP1, and G9a histone H3K9 methyltransferase. In conclusion, we identified a novel mechanism underlying pericentromeric heterochromatin formation mediated by ZNF518.

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