Complete blood count and selected serum parameters of Venus transgenic rabbits
Biro, B.; Skoda, G.; Hoffmann, O. I.; Hiripi, L.; Gocza, E.; Liptak, N.
Show abstract
Green fluorescent protein (GFP) transgenic laboratory animals (mice, rats, rabbits etc.) are commonly used in basic research for modelling human diseases, studying organ development, cell transfer during pregnancy or tissue engineering. The expression of the fluorescent protein can be either ubiquitous or tissue-specific, depending on the transgenic construct and the integration site of the transgene. Despite the wide applications, the data about the physiological parameters of GFP transgenic animals are limited. In most of the transgenic lines, GFP does not induce any detrimental effect, but GFP-induced conditions are also reported. Altered T-lymphopoiesis and low white blood cell (WBC) count were observed in human ubiquitin C promoter-driven GFP transgenic (UBC-GFP) mice due to latent stem cell defect. The aim of the present study was to examine the effects of the Venus fluorescent protein on hematopoiesis and general health of transgenic rabbits, thus, hematology along with selected serum parameters were measured.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Impact of gestational low-protein intake on embryonic kidney microRNA expression and in the nephron progenitor cells of the male offspring fetus 94%
- Circulating miR-30b-5p is up regulated in Cavalier King Charles Spaniels affected by early myxomatous mitral valve disease 93%
- Capillary hemoglobin electrophoresis of healthy and anemic dogs: quantification, validation, and reference intervals of hemoglobin fractions 93%
Similar papers in this journal
- A comparative meta and in silico analysis of differentially expressed genes and proteins in canine and human bladder cancer 93%
- Interplay between stress and reproduction: Novel epigenetic markers in response to shearing patterns in Australian Merino sheep (Ovis aries) 92%
- Serum levels and tumour expression of leptin and leptin receptor as promising clinical biomarkers of specific feline mammary carcinoma subtypes 91%
Similar papers in this journal
- A computational approach for mapping heme biology in the context of hemolytic disorders 87%
- Let-7i-5p regulation of cell morphology and migration through distinct signaling pathways in normal and pathogenic fibroblasts from urethra 87%
- Monitoring group activity of hamsters and mice as a novel tool to evaluate COVID-19 progression, convalescence and rVSV-ΔG-spike vaccination efficacy 87%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.