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Cross-amplified Barcodes on Slides for Spatial Transcriptomics Sequencing

JIN, Z.; Yu, N.; Bai, J.; Liu, Z.; Li, H.; Zhang, J.; Liang, C.

2022-08-26 genomics
10.1101/2022.08.25.504658 bioRxiv
Show abstract

Spatial transcriptomics can reveal molecular signatures of tissue at spatial scales, but current technologies cannot integrate excellent accessibility and easy data-decoding. Here, we use oligonucleotides whose number is the square root of the number of spots to generate cross-amplified spatial barcodes on slides using microfluidic technology. This method can obtain microarrays with well-defined barcodes easily and at low cost, without post-decoding, which contributes to the popularization of spatial transcriptomics.

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