JNK signalling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosis
Nguyen, L.; Westerhoff, M.; Thewes, L.; Wruck, W.; Reichert, A. S.; Berndt, C.; Adjaye, J.
Show abstract
With a global increase in chronic kidney disease patients, alternatives to dialysis and organ transplantation are needed. Stem cell-based therapies could be one possibility to treat chronic kidney disease. Here, we used multipotent urine-derived renal progenitor cells (UdRPCs) to study nephrogenesis. UdRPCs treated with the JNK inhibitor-AEG3482, displayed decreased proliferation and downregulated transcription of cell cycle-associated genes as well as the kidney progenitor markers -SIX2, CITED1, and SALL1. In addition, levels of activated SMAD2/3, which is associated with the maintenance of self-renewal in UdRPCs, were decreased. JNK inhibition resulted in less efficient oxidative phosphorylation and more lipid peroxidation via ferroptosis-an iron-dependent non-apoptotic cell death pathway linked to various forms of kidney disease. Our study reveals the importance of JNK signalling in maintaining self-renewal as well as protection against ferroptosis in SIX2-positive UdRPCs. We propose that UdRPCs can be used for modelling ferroptosis-induced kidney diseases.
Matching journals
The top 12 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Derivation of the immortalized cell line-UM51-PrePodo-hTERT and its responsiveness to Angiotensin II and activation of RAAS 96%
- Human iPSC-derived renal cells change their immunogenic properties during maturation: Implications for regenerative therapies 94%
- Anti-apoptotic and anti-inflammatory properties of grapefruit IntegroPectin on human microglial HMC3 cell line 92%
Similar papers in this journal
- Temporal and sex-dependent gene expression patterns in a renal ischemia-reperfusion injury and recovery pig model 95%
- The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis 94%
- Glomerular spatial transcriptomics of IgA nephropathy according to the presence of mesangial proliferation 94%
Similar papers in this journal
- Impact of gestational low-protein intake on embryonic kidney microRNA expression and in the nephron progenitor cells of the male offspring fetus 96%
- Impact of maternal protein restriction on hypoxia-inducible factor (HIF) expression in male fetal kidney development 95%
- Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release 95%
Similar papers in this journal
- AMPK is dispensable for physiological podocyte and glomerular functions but prevents glomerular fibrosis in experimental diabetes 94%
- ELMO1 dependent efferocytosis protects from nephrotoxin induced acute kidney injury 91%
- Tumors cells with mismatch repair deficiency induce hyperactivation of Pyroptosis resistant to cell membrane damage but are more sensitive to Co-treatment of IFN-γ and TNF-α to PANoptosis 91%
Similar papers in this journal
- Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells 93%
- Physoxia influences global and gene-specific methylation in pluripotent stem cells 93%
- NDR2 Kinase Regulate Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.