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Development and validation of glycolysis-cholesterol synthesis genes in lung adenocarcinoma

Qian, B.; Guo, Y.; Jiang, J.

2022-08-15 genetics
10.1101/2022.08.15.503983 bioRxiv
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BackgroundLung adenocarcinoma (LUAD) is the most common subtype of lung cancer which is one of the most dangerous malignant tumors affecting human health. The pathways of glycolysis and cholesterol production play an essential role in the metabolism of cancer. The mitochondrial pyruvate carrier (MPC) consists of MPC1 and MPC2, and impaired MPC function may induce a solid capacity for tumor proliferation, migration, and invasion. MethodsGenes positively and negatively correlated with MPC1/2 expression were identified by calculating Spearman correlation, then gene ontology (GO) analysis was conducted. Univariate cox regression, lasso regression, and multivariate cox regression analyses were performed to model predictive outcome events using differentially expressed genes. Thirteen prognostic genes were selected to construct a prognostic model. Results1359 and 2026 genes were positively and negatively associated with MPC1/2, respectively. The expression of MPC1 and MPC2 was significantly different. The prognostic model had great predictive performance in the test set. ConclusionsMPC1/2 genes were involved in a cellular network associated with the malignant development of LUAD. The prognostic model can provide an essential basis for physicians to predict the clinical outcomes of LUAD patients.

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