Multiple-region Gray Matter Atrophy contribute to freezing of gait in Parkinson's Disease
Zhang, S.; Huang, J.; Liu, D.; Yin, Y.; He, H.; Hu, K.
Show abstract
ObjectiveThe aim of our study was to detect the localization of gray matter atrophy in FOG PD patients compared with nFOG PD patients. MethodsA total of 155 PD patients (110 men and 45 women) were included in the current study. Forty-five patients were classified as FOG and one hundred and ten patients were classified as nFOG. A voxel-based morphometry approach was used to investigate the atrophy area of voxel clusters in the gray matter which is associated with FOG. ResultsFOG and nFOG PD patients were not significantly different in gender, average age, educational years, disease duration or UPDRS-part I. Compared with nFOG PD patients, FOG patients showed gray matter atrophy in right Inferior frontal gyrus (opercular part), left Superior frontal gyrus, left Superior temporal gyrus, left Amygdala, left Insula, left Medial superior frontal gyrus and left Medial frontal gyrus (orbital gyrus). ConclusionOur study identified new gray matter atrophy areas in FOG PD patients compared with nFOG patients.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Longitudinal brain structure changes in Parkinson's disease: a replication study 97%
- Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease 97%
- Relationship between finger movement characteristics and voxel-based specific regional analysis systems for Alzheimer’s disease 95%
Similar papers in this journal
- Asymptomatic carriers of the p.A53T SNCA mutation: data from the PPMI study 95%
- Predicting Longitudinal Disease Severity for Individuals with Parkinson's Disease using Functional MRI and Machine Learning Prognostic Models 95%
- impaired bed mobility in prediagnostic and de novo Parkinson’s disease 94%
Similar papers in this journal
- Exploring Motor Imagery as a Therapeutic Intervention for Parkinson’s Disease Patients: A Scoping Review 94%
- Vagus nerve cross-sectional area in patients with Parkinson’s Disease – an ultrasound case-control study 93%
- Clinical and genetic analysis of Costa Rican patients with Parkinson's disease. 93%
Similar papers in this journal
- Distinct Longitudinal Clinical-Neuroanatomical Trajectories in Parkinson’s Disease Clinical Subtypes: Insight Towards Precision Medicine 94%
- Diversity in Parkinson’s disease genetics research: current landscape and future directions 93%
- The non-coding GBA1 rs3115534 variant is associated with REM sleep behavior disorder in Nigerians 93%
Similar papers in this journal
- Subregional analysis of the amygdala, thalamus, and hypothalamus at the pre-decline stage in Parkinson’s disease groups with later cognitive impairment 97%
- Behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice 92%
- A pH-eQTL interaction at the RIT2-SYT4 Parkinson's disease risk locus in the substantia nigra 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.