SARS-CoV-2 BA.4 infection triggers more cross-reactive neutralizing antibodies than BA.1
Richardson, S.; Motlou, T.; van der Mescht, M.; Lambson, B.; Everatt, J.; Amoako, D.; Van Gottberg, A.; Wolter, N.; de Beer, Z.; Roma de Villiers, T.; Bodenstein, A.; van den Berg, G.; Rossouw, T. M.; Boswell, M.; Ueckermann, V.; Bhiman, J.; Moore, P.
Show abstract
SARS-CoV-2 variants of concern (VOCs) differentially trigger neutralizing antibodies with variable cross-neutralizing capacity. Here we show that unlike SARS-CoV-2 Omicron BA.1, which triggered neutralizing antibodies with limited cross-reactivity, BA.4/5 infection triggers highly cross-reactive neutralizing antibodies. Cross-reactivity was observed both in the absence of prior vaccination and also in breakthrough infections following vaccination. This suggests that next-generation vaccines incorporating BA.4, which is spreading globally, might result in enhanced neutralization breadth.
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