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Causal linkage of tobacco smoking with ageing traits: a Mendelian randomization analysis towards telomere attrition and frailty

2022-06-27 geriatric medicine Title + abstract only
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BackgroundAgeing traits and frailty are important health issues in modern medicine. Evidence supporting the causal effects from tobacco smoking on various ageing traits is warranted. MethodsThis Mendelian randomization (MR) analysis instrumented 377 genetic variants associated with being an ever smoker in a genome-wide significant level to test the causal estimates from tobacco smoking. The outcome data included 337,318 white British ancestry UK Biobank participants. Leukocyte telomere length, ...

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