Yin-Yang 1, a player regulated systematic inflammatory involved in cognitive impairment of depression

A growing number of clinical and preclinical studies suggest that alterations in peripheral and brain immunal system and followed inflammation are associated with the pathophysiology of depression, also leading to the changes in local glucose metabolism in the brain. Here, we identified Yin-yang 1 (YY1), a transcription factor that has been reported to be closely associated with central and peripheral inflammation. The levels of YY1 and IL-1{beta} were significantly increased in blood samples from depressed individuals, and significantly decreased after treatment with Vortioxetine. Meanwhile, it was found that the level of YY1 in plasma was negatively correlated with visual learning reasoning and problem solving in MDD patients, and positively correlated with the level of IL-1{beta} in plasma. CUMS animals showed depressive-like behavior. Compared with the control group, MicroPET analysis showed that the decrease of glucose metabolism in the hippocampus, entorhinal cortex, amygdala, striatum and mPFC was reversed after treatment. After treatment, these changes were reversed. In conclusion, Our study suggested that YY1-NF-{kappa}B - IL-1{beta} inflammatory pathway may play an essential part on both mood changes and cognitive impairment in depression, and may be associated with changes in glucose metabolism in the emotion regulation and cognition related brain regions. These findings provide new evidence for the inflammatory mechanisms of depression.