Prevalence of Neutralizing Antibodies against Adenoviruses types -C5, -D26 and -B35 used in vaccination platforms, in Healthy and HIV-Infected Adults and Children from Burkina Faso and Chad
Ouoba, A. R.; Paris, O.; Adawaye, C.; Dzomo, G. T.; Fouda, A. A.; Kania, D.; Diarra, A.; Kallo, Z. A.; Traore, I. T.; Sirima, S. B.; Tuaillon, E.; Van de Perre, P.; Kremer, E. J.; Mennechet, F. J. D.
Show abstract
Vaccines derived from human adenoviruses (HAdV) are currently being used and trialed against numerous infectious agents. However, pre-existing humoral immunity can impair vaccines efficacy and safety. Strategies to circumvent this immunity often involve the use of vectors with lower seroprevalence. We evaluated HAdV-C5, HAdV-D26 and HAdV-B35 seroprevalence from healthy and HIV-infected populations from Burkina Faso and Chad. Seroprevalence for HAdV-C5 was high and comparable between countries (54%-66%), and the highest in the HIV-infected groups from sub-Saharan regions ([~]90%). However, compared to France (4%), seroprevalence for HAdV-D26 was significantly higher in sub- Saharan groups ([~]47%). By contrast, HAdV-B35 seroprevalence was low for all groups tested. We also found that HAdV-D26 complexed with immunoglobulins induced strong activation of dendritic cells in vitro. Our study fills gaps in the epidemiological data needed to optimize HAdV-derived vaccines in sub-Saharan regions, and highlights the necessity to better adjust vaccination strategies in Africa. Article summary lineHAdVs Seroprevalence in Burkina Faso and Chad
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