Study of the glycome of synovial mast cells in normal tissues, osteoarthritis and rheumatoid arthritis reveals MGAT5 activity in these and endochondral cells.
McClure, J.; McClure, S. F.
Show abstract
Mast cells and angiogenesis play roles in the synovium of both osteoarthritis and rheumatoid disease but precise mechanisms are unclear. In a study of the glycome of human synovial biopsies from normal, osteoarthritic and rheumatoid disease cases mast cell numbers were increased in both osteoarthritic and rheumatoid disease synovial samples (the latter more than the former). Both mast cells and endothelial cells expressed receptors for the lectin Phaseolus vulgaris leukagglutinin (lPHA). Endothelial cells only expressed receptors for Psophocarpus tetragonolobus (PTL-II). Mast cells and angiogenesis are, therefore, likely to have a common pathogenetic mechanism in osteoarthritis and rheumatoid synovitis, the difference being one of degree. lPHA receptor expression in both mast cells and endothelial cells indicates {beta}l,6N-acetylglucosaminyl (GlcNAc) - transferase V (GnTaseV/MGAT5) activity. This provides a linkage between mast cells and endothelial cell proliferation. Endothelial cells show core 1 O-glycosylation (positive PTL-II staining) which is probably necessary for the formation of competent tubular structures and for continuing vascular integrity.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Anti-inflammatory role of APRIL by modulating regulatory B cells in antigen-induced arthritis 93%
- An ex vivo tissue model of cartilage degradation suggests that cartilage state can be determined from secreted key protein patterns 93%
- Detection of apoptosis and matrical degeneration within the intervertebral discs of rats due to passive cigarette smoking. 93%
Similar papers in this journal
- Computer vision detects inflammatory arthritis in standardized smartphone photographs in an Indian patient cohort 92%
- Comparison of volumetric brain analysis in subjects with rheumatoid arthritis and ulcerative colitis 91%
- Subchondral H-type Blood Vessel Formation Aggravates Articular Cartilage Degeneration through LEP-LEPR Axis 91%
Similar papers in this journal
- Pathological classification of Fuchs endothelial corneal dystrophy in several types and their relationships with CTG18.1 expansion repeats 89%
- Cell Stiffening Contributes to Complement-mediated Injury of Choroidal Endothelial Cells in Early AMD 86%
- Spatial Effects of Infiltrating T cells on Neighbouring Cancer Cells and Prognosis in Stage III CRC patients 85%
Similar papers in this journal
- Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients 93%
- Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice 92%
- The Heparan Sulfate Proteoglycan Syndecan-1 Influences Local Bone Cell Communication via the RANKL/OPG Axis 91%
Similar papers in this journal
- Downregulation of insulin-like growth factor binding protein 5 is involved in intervertebral disc degeneration via the ERK signaling pathway 92%
- Super-resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement 87%
- Dendritic cell-derived lncRNA in patients with acute coronary syndrome 86%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.