Analysis of the All of Us Research Program Researcher Workbench Workspaces

The All of Us Research Program, through the All of Us Research Hub platforms Researcher Workbench, provides researchers and citizen scientists with access to a broad dataset of surveys, electronic health records, physical measurements, genetic data, and Fitbit device wearable data. All of Us has a goal of recruiting a minimum of one million participants and aims to capture the diversity of individuals in the United States. The All of Us Research Hub platform includes a Research Projects Directory on its website, displaying researcher-provided descriptions of each active workspace on the Researcher Workbench. Inspired by the initial work completed by All of Us investigators in 2019, these workspace descriptions were analyzed with a new methodology. Genetic, methods and validation studies, and educational research purposes were associated with disease-focused research, as compared to non-disease focused research. Of all the population categories of interest, only race and ethnicity were associated with disease-focused research. Further categorization of the disease-focused workspaces revealed the top five disease categories: cardiovascular disease, brain and mental health disorders, cancer and benign tumors, diabetes, and immunology-related conditions. Athena OHDSI catalog terms were sorted and helped classify the workspaces by each disease category. Subcategory distribution for the cancer, genetic, and cardiovascular disease-related conditions was examined as well. This framework has the potential to be used for continued longitudinal analysis of the workspaces and continued learnings regarding the importance of disease-focused research in public health. Additionally, as workspace descriptions are created at project initiation, this can provide us with a leading-edge indication of researcher interest in the All of Us Research Program data.