The Application of Trimetazidine in Healthy Individuals: A Systematic Review

BackgroundCurrently, there is no evidence to support TMZ administration aiming to enhance any parameter of physical performance or post-exercise recovery in healthy individuals of the general population and athletes. ObjectiveConsidering the lack of empirical data, from a scientific and practical perspective it would be interesting to identify research with high methodological quality that examines the effects of trimetazidine (TMZ) on healthy individuals of the general population and athletes of varying age. MethodsData sources included English articles that were searched by keywords in the PubMed and Scopus databases and the Cochrane Library and published prior to November 2022. Thus, a systematic review of the scientific literature was performed utilizing databases with a traditional PRISMA methodology. An initial search by keyword found 2673 publications and the screening process selected 66 articles, of which two articles met the inclusion criteria. ResultsTwo trials examining the effect of TMZ on healthy members of the general population that were published in 2017 and 2019 were analyzed. Athletes were not recruited for this type of research. ConclusionsCurrently there are no data reporting a positive effect of TMZ on physical performance, post-exercise recovery, or other health parameters in members of the general population, while its administration is associated with the development of relatively common adverse effects.