Higher contact among vaccinated can be a mechanism for negative vaccine effectiveness
Bodner, K.; Knight, J.; Hamilton, M. A.; Mishra, S.
Show abstract
Evidence from early observational studies suggested negative vaccine effectiveness for the SARS-CoV-2 Omicron variant. Using transmission modeling, we illustrated how increased contact between vaccinated individuals, vaccinated contact heterogeneity, paired with lower vaccine efficacies could produce negative measurements and how we can identify this mechanism via a key temporal signature.
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