Restriction of dietary fat, but not carbohydrate, alters brain reward circuitry in adults with obesity
Darcey, V. L.; Guo, J.; Courville, A.; Gallagher, I.; Avery, J. A.; Simmons, W. K.; Ingeholm, J. E.; Herscovitch, P.; Martin, A.; Hall, K. D.
Show abstract
Weight loss diets often target restriction of dietary fat or carbohydrate, macronutrients that are sensed via distinct gut-brain pathways and differentially affect peripheral hormones and metabolism. However, the effects of such diet changes on human brain are unclear. We investigated whether selective isocaloric reductions in dietary fat or carbohydrate altered dopamine D2/3 receptor binding potential (D2BP) and neural activity in brain reward regions in response to visual food cues in 17 inpatient adults with obesity as compared to a eucaloric baseline diet. On the fifth day of dietary fat restriction, but not carbohydrate restriction, both D2BP and neural activity to food cues were decreased in brain reward regions. After the reduced fat diet, ad libitum intake shifted towards foods high in both fat and carbohydrates. These results suggest that dietary fat restriction increases tonic dopamine in brain reward regions and affects food choice in ways that may hamper diet adherence.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Unraveling Interoceptive Processing and Action Dynamics: Exploring Neural and Psychological Responses to Food Cues Using fMRI 93%
- Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats 92%
- Working Memory Gating in Obesity: Insights from a Case-Control fMRI Study 92%
Similar papers in this journal
- Fat and carbohydrate interact to potentiate food reward in healthy weight but not in overweight or obesity 93%
- The effects of time-restricted eating vs. standard dietary advice on weight, metabolic health and the consumption of processed food: A pragmatic randomised controlled trial in community-based adults 92%
- Almond Consumption Improves Inflammatory Profiles Independent of Weight Change: A 6-Week Randomized Controlled Trial in Adults with Obesity 91%
Similar papers in this journal
- The neural pathways of change: An fMRI study of the effects of behavioral change suggestions on value-based dietary decision-making. 95%
- Higher BMI, but not obesity-related genetic polymorphisms, correlates with reduced structural connectivity of the reward network 91%
- Joint associations between objectively measured physical activity volume and intensity with body-fatness. The Fenland Study 91%
Similar papers in this journal
- Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in liver and adipose tissue 91%
- How Food Environment Impacts Dietary Consumption and Body Weight: A Country-wide Observational Study of 2.3 Billion Food Logs 91%
- Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.