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Antifungal activity of Cinnamomum cassia and Origanum compactum essential oils against Aspergillus oryzae

Leclercq, M.; Commenge, I.; Bouriot, M.; Crusset, F.; Gonzalez, P.; Grimaud, J.; Yates, F.; Sarfati-Bert, J.; Saint-Pol, A.

2022-03-24 microbiology
10.1101/2022.03.24.485625 bioRxiv
Show abstract

Aspergillosis is a nosocomial disease that usually affects the respiratory system. While most patients develop mild symptoms, aspergillosis can become a serious health threat in immunocompromised populations and patients with pre-existing respiratory conditions. Aspergillosis is caused by fungi of the Aspergillus genus. Existing treatments include drugs such as amphotericin B, with strong side effects. Numerous studies have shown the antifungal properties of essential oils (EOs), which represent potential alternative treatments against fungal infections. Here, we screened the antifungal properties of five EOs against Aspergillus oryzae: Melaleuca alternifolia, Mentha x piperita, Thymus zygis, Origanum compactum, and Cinnamomum cassia. Of the five EOs, two demonstrated antifungal activity: Origanum compactum acted as a fungistatic, while Cinnamomum cassia showed both fungistatic and fungicidal effects against A. oryzae. Therefore, both EOs represent potential alternative treatments against Aspergillosis.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.