E-cigarette vapour from base components propylene glycol and vegetable glycerine inhibits inflammatory response in macrophages and epithelial cells
Bell, R. L.; McAuley, D. F.; Shyamsundar, M.; O'Kane, C. M.; Dombrowski, Y.
Show abstract
E-cigarettes are a highly popular nicotine replacement therapy in the process of smoking cessation. Despite this, research on the effects of E-vapours to human health remains limited. The popularity of vaping and mass production of cheap E-liquids has led to compromised safety regulations, with contaminants such as heavy metals and alkaloids detected in multiple liquids. Vaporised E-liquids increase cellular ROS generation and inflammatory cytokine release from pulmonary macrophages. This suggests that E-cigarette usage might activate inflammasomes. Common food additives vegetable glycerine (VG) and propylene glycol (PG) form the base of all E-liquids, but little is known about their inflammatory potential once inhaled. Here, the effect of base components PG and VG on inflammasome activation and cytokine release was investigated in macrophages and epithelial cells exposed to E-liquids and vaporised E-liquid extract (E-vapour). Base E-liquid and E-vapour did not induce cellular cytotoxicity and non-vapourised E-liquid had no effect on IL-8 release. However, basic PG/VG E-vapour inhibited both IL-8 release and conventional inflammasome activation by known inflammatory activators in macrophages and epithelial cells. These results propose a novel inhibitory effect of basic E-vapour components to inflammatory challenges.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Development and validation of an open-source, disposable, 3D-printed in vitro environmental exposure system for Transwell culture inserts 95%
- Development and validation of a mouse model of contemporary cannabis smoke exposure 94%
- Open-source 3D printed manifolds for exposure studies using human airway epithelial cells 93%
Similar papers in this journal
- Revealing the impact of Pseudomonas aeruginosa quorum sensing molecule 2'-aminoacetophenone on human bronchial-airway epithelium and pulmonary endothelium using a human airway-on-a-chip 93%
- Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis. 93%
- The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages 93%
Similar papers in this journal
- Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice 94%
- Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs 93%
- Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo. 92%
Similar papers in this journal
- HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD 94%
- Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells 93%
- Neonatal endotoxin stimulation was associated with long- term innate immune markers and an anti-allergic response in bronchiolar epithelium in spite of allergen challenge 92%
Similar papers in this journal
- Human pulmonary neuroendocrine cells respond to House dust mite extract with PAR-1 dependent release of CGRP 93%
- Distribution of ACE2, CD147, cyclophilins, CD26 and other SARS-CoV-2 associated molecules in human tissues and immune cells in health and disease 91%
- Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.