Early Tactile Stimulation Influences the Development of Alzheimer Disease in Gestationally Stressed APPNL-G-F/ NL-G-F Adult mice
Hossain, S.; Jafari, Z.; Karem, H.; Kolb, B.; Mohajerani, M.
Show abstract
Alzheimer Disease (AD) is associated with cerebral plaques and tangles, reduced synapse number, and shrinkage in several brain areas and these morphological effects are associated with the onset of compromised cognitive, motor, and anxiety-like behaviours. The focus of this study was to examine the effect of neonatal tactile stimulation on AD-like behavioural and neurological symptoms on APP NL-G-F/NL-G-F mice, a mouse model of AD. Our findings indicate that neonatal tactile stimulation improves cognition, motor skills, and anxiety-like symptoms in both gestationally stressed and non-stressed adult APP mice and that these alterations are associated with reduced A{beta} plaque formation. Thus, tactile stimulation appears to be a promising non-invasive preventative strategy for slowing the onset of dementia in aging animals.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Impaired learning and memory ability induced by a bilaterally hippocampal injection of streptozotocin in mice: involved with the adaptive changes of synaptic plasticity 95%
- Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice 93%
- Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer's disease mice 93%
Similar papers in this journal
- Probucol mitigates high-fat diet-induced cognitive and social impairments through disruption of redox-inflammation association 92%
- A human embryonic stem cell model of Aβ-dependent chronic progressive neurodegeneration 92%
- The therapeutic and diagnostic potential of amyloid β oligomers (AβOs) selective antibodies to treat Alzheimer's disease 91%
Similar papers in this journal
- Telomere length and oxidative stress variations in a murine model of Alzheimer's disease progression 96%
- Ketone ester-enriched diet ameliorates motor and dopamine release deficits in MitoPark mice 93%
- Non-invasive brain stimulation protects cognitive impairment in i.c.v.STZ injected rats: role of adult neurogenesis 92%
Similar papers in this journal
- Altered Hippocampal Glutamatergic Neurotransmission and Cognitive Impairment in APP Knock-In Mice 94%
- Effects of memantine and high dose vitamin D on gait in the APP/PS1 mouse model of Alzheimer's disease following vitamin D deprivation 94%
- Association of GLOD4 with Alzheimers Disease in Humans and Mice 93%
Similar papers in this journal
- The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease 93%
- Amyloid Precursor Protein (APP) controls excitatory/inhibitory synaptic inputs by regulating the transcriptional activator Neuronal PAS Domain Protein 4 (NPAS4) 92%
- Postnatal fluoxetine treatment alters perineuronal net formation and maintenance in the hippocampus 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.