BML-257, a small molecule that protects against drug induced liver injury in zebrafish
Jagtap, U.; Basu, S.; Lokhande, L.; Bharti, N.; Sachidanandan, C.
Show abstract
The use of many essential drugs is restricted due to their deleterious effects on the liver. Molecules that can prevent or protect the liver from drug induced liver injury (DILI) would be valuable in such situations. We used hepatocyte-specific expression of bacterial nitroreductase in zebrafish to cause temporally controlled liver damage. This transgenic line was used to run a whole organism based chemical screen in zebrafish larvae. In this screen we identified BML-257, a potent small molecule AKT inhibitor, that protected the liver against metronidazole-induced liver injury. BML-257 also showed potent prophylactic and pro-regenerative activity in this liver damage model. BML-257 also showed remarkable protective action in two independent toxicological models of liver injury caused by acetaminophen and Isoniazid. This suggests that BML-257 may have the potential to protect against multiple kinds of drug induced liver injury.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish 95%
- Analyzing cannabinoid-induced abnormal behavior in a zebrafish model 94%
- Consecutive treatments of methamphetamine promote the 4 development of cardiac pathological symptoms in zebrafish 94%
Similar papers in this journal
- The combination of lipopolysaccharide and D-galactosamine administration show positive genotoxic effect in mice liver 94%
- Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure 93%
- Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models 93%
Similar papers in this journal
- Unraveling the Potential Role of Tecomella undulata in Experimental NASH 94%
- An Evaluation of the In Vitro Roles and Mechanisms of Silibinin in Reducing Pyrazinamide- and Isoniazid-Induced Hepatocellular Damage 94%
- Inhibitory effects of β-caryophyllene on Helicobacter pylori infection in vitro and in vivo 93%
Similar papers in this journal
- JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation 93%
- Zebrafish Drug Screening Identifies Erlotinib as an Inhibitor of Wnt/β-Catenin Signaling and Self-Renewal in T-cell Acute Lymphoblastic Leukemia 91%
- Pro-cognitive Effects of Dual Tacrine Derivatives Acting as Cholinesterase Inhibitors and NMDA Receptor Antagonists 91%
Similar papers in this journal
- Macrolactin A Is an Inhibitor of Protein Biosynthesis in Bacteria 91%
- Functional Role of Annexins in Zebrafish Caudal Fin Regeneration: A Gene Knockdown Approach in Regenerating Tissue. 90%
- Cell-penetrating peptide and cationic liposomes mediated siRNA delivery to arrest growth of chronic myeloid leukemia cells in vitro 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.